Aim - Resting Study

AIMS

The primary aim of the study is to evaluate the prognostic value of exosomal and cell-free miRNAs in relation to disease-free survival (DFS) and overall survival (OS) in a prospective cohort of resected early-stage (stages IA-IIIA) NSCLC patients. Secondary aims are:

To evaluate the prognostic value of fcDNA.
To evaluate the prognostic value of miRNAs in other (non exosomal) microvesicles.
To evaluate the prognostic value of miRNAs in tumor tissue.
To investigate the associations between the different types of biomarkers and the impact of their combination in relation to patient prognosis.
To compare the expression pattern of miRNAs in plasma and matched tumor tissue.
To compare the expression pattern of miRNAs in exosomes and other microvesicles.

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